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 File NameSizeNotes
 CRMSimulator_V5.3_NoFX1.1.exe  3416 KB No Microsoft .Net Framework included. Assumes you already have the .NET 1.1 Framework installed
 CRMSimulator_V5.3_WithFX1.1.exe  25660 KB Includes Microsoft .Net Framework 1.1
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CRM Simulator

The CRMSimulator is an easy-to-use implementation of the CRM dose-finding method of Quigley, Pepe, and Fisher. The emphasis of this version is simplicity, not generality; many features of previous versions which were not commonly used have been removed. This software provides a simple setting in which to experiment with adaptive dose-finding. A more general command line implementation of the CRM is available here.

Investigators interested in finding an effective dose and not just a moderately toxic dose may be interested in the EffTox dose-finding method.

 

 

See also the CRM method description and CRMSimulator user's guide available here and also included with the software.

Clift Norris developed the user interface using C# and the Microsoft .NET framework version 1.1.

John Cook implemented the simulation kernel using Visual C++.