CRM
Continual Reassessment Method (CRM) For Dose-finding In Phase I Clinical Trials
CRM version 1.0 is a menu-driven command-line computer program which implements
the Continual Reassessment Method (CRM) for dose-finding in Phase I
clinical trials. It is designed for use by physicians, research
nurses and statisticians. It provides a means to log in patients as
they are accrued to the trial, to record their outcomes from treatment
("toxicity'" or "no toxicity'"). The program selects doses for
successive cohorts of patients based on the current data using the
Bayesian method underlying the CRM.
The CRM was originally proposed by O'Quigley, Pepe and Fisher in 1990
in the paper cited below. The documentation accompanying the package
also contains a fairly complete bibliography.
A simplified version of the CRM called
CRM Simulator
is also available from this download site. The CRM Simulator
retains the most commonly used features of the original CRM and has a Windows
user interface.
Also, investigators interested
in finding an effective dose and not just a moderately toxic dose may be
interested in the
EffTox dose-finding method.
This software was developed by John Venier.
References
O'Quigley, J., Pepe, M. Fisher, L. (1990) "Continual reassessment
method: a practical design for phase I clinical trials in
cancer." Biometrics 46, 33-48.
Language: Fortran 77
