Dose Schedule Finder

Design and conduct Phase I clinical trials that simultaneously optimizes dose and schedule

This software is for designing and conducting Phase I clinical trials that simultaneously optimizes both dose and schedule. The goal is to determine a maximum-tolerated dose and schedule (MTDS) in terms of the overall risk of toxicity. The method is Bayesian adaptive and uses time-to-toxicity as the outcome.

The software is based on the paper Simultaneously optimizing dose and schedule of a new cytotoxic agent, Thomas M Braun, Peter F Thall, Hoang Nguyen, and Marcos de Lima, Clinical Trials 2007; 4: 113–124.

Hoang Nguyen developed the numerical algorithms using Visual C++, and the user interface using C# and the Microsoft .NET framework version 2.0