SEQBINBayesian/Frequentist Designs for Sequential/GroupSequential
Trials of a Single Binomial ParameterDescriptionThis program creates Bayesian designs for either a sequential or
groupsequential singlesample binomial trial. In particular, let
theta be the probability of the event of interest (which in clinical
trials could be either toxicity or response). The trial terminates
when there is sufficient evidence that the chosen one of the three
conditions holds, where p_{h0} is a userspecified null hypothesis value
of theta. A Bayesian design method is used: the designer specifies a
beta prior distribution on theta; the trial ceases when the posterior
distribution posits that the probability that theta is greater than
(or less than depending on the direction of the test) p_{h0} is
sufficiently large. For a frequentist, the value of sufficiently
large can be calculated to provide (close to) a specified significance
level. Contact: Barry W. Brown Language: Fortran 95
