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Allele Frequency Estimation From Small Pool PCR Data


In small pool PCR, very small amounts of DNA are amplified so that only, on average, two or so alleles are seen. The examination of a sample is replicated many (perhaps 100) times. Data consists of the number of replicate examinations in which a particular allele was seen. From this data, the frequency of all alleles is estimated along with the variation in this estimate.

Contact: Barry W. Brown

Language: Fortran 77