bCRM: Bivariate Continual Reassessment Method
The bCRM is based on the algorithms given in the following two papers:
- Goodman, S.N., Zahurak, M.L., and Piantadosi, S.
"Some Practical Improvements in the Continual Reassessment Method for Phase I Studies."
Statistics in Medicine, 14(11):1149-1161, 1995.
- Braun, TM. "The Bivariate CRM: Extending the CRM to Phase I Trials
of Two Competing Outcomes. Controlled Clinical Trials, 23, 240-255, 2002.
The application user guides are available below:
The installer and application require the Java runtime v1.4.2_01 which is
bundled with the download.
bCRM is the product of the collective efforts of the following people from Tessella:
Geraint Lloyd
Robert Nelson
Nick Battam
Tom Parke
Alistair Culf
Stephen Joyce.