U2OET
Phase I-II dose-pair-finding based on utilities of 4-level ordinal
efficacy and toxicity
U2OET is a Windows command line program implementing the
dose-pair-finding method described in detail in the paper “Parametric Dose Standardisation
for Optimising Two-Agent Combinations in a Phase I-II Trial with Ordinal
Outcomes”, by Thall, Nguyen, and Zinner (Journal of the Royal Statistical Society - Series C, 2016).
This is an extension of the method previously described in the paper
“Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity
and Efficacy in Phase I/II Trials”, by Houede, Thall, Nguyen, Paoletti, and
Kramar (Biometrics, 2010).
Please read these papers carefully before using this computer program.
A preprint of the papers may be obtained by contacting Peter Thall.
This computer program was written by Hoang Nguyen using Visual C++.