MULTC
Multiple Outcomes in Clinical Trials
Description
Multc is the name applied to the
design strategy for monitoring multiple outcomes in clinical trials
described in the papers given in references below.
There are two software implementations of this method.
The first, and most general, is the commandline program Multc99,
available for download here. This version was developed in C by Hsi-Guang Sung.
A newer version, Multc Lean, retains the most commonly
used features of Multc99 and has a simplified user interface.
This technical report
investigates the time required to conduct a clinical trial using this method.
References
Thall, Peter F., Simon, R. and
Estey, E.H. "Bayesian sequential
monitoring designs for single-arm clinical trials with multiple
outcomes," Statistics in Medicine 14:357-379, 1995.
Thall, Peter F., Simon, R. and
Estey, E.H. "New statistical
strategy for monitoring safety and efficacy in single-arm clinical
trials," J. Clinical Oncology 14:296-303, 1996.
Thall, Peter F. and Sung, Hsi-Guang, "Some Extensions and
Applications of a Bayesian Strategy for Monitoring Multiple Outcomes
in Clinical Trials." Statistics in Medicine. (In press as of December,
1997).