aPCoA: Covariate Adjusted Principal Coordinates Analysis

  PID:1033   Version:1.3   Last updated: 2025-09-10
  Yushu Shi1, Liangliang Zhang2, Kim-Anh Do2, Christine Peterson2, and Robert Jenq3
  Contact email:   shiyushu2006@gmail.com

Step 1: Provide meta data and distance matrix


Example dataset from an ecology study is provided
Download example meta data

Download example distance matrix

Step 2: Run aPCoA


Select main covariate and 'nuisance' covariate to adjust for

  • Information
  • Result
Download plots Download aPCoA plot information
  1:   Department of Statisitcs, the University of Missouri, Columbia
  2:   Department of Biostatistics, the University of Texas, MD Anderson Cancer Center
  3:   Department of Genomic Medicine,the University of Texas, MD Anderson Cancer Center
  Reference: Yushu Shi, Liangliang Zhang, Kim-Anh Do, Christine B Peterson, Robert Jenq, aPCoA: Covariate Adjusted Principal Coordinates Analysis, Bioinformatics,btaa276
  https://doi.org/10.1093/bioinformatics/btaa276
  Special thanks to Clift Norris and Ying-Wei Kuo for their suggestions and support in making this app.
  Special thanks to Guojun Wu for helping us fix the bug in verison 1.1.