Simon's Two-Stage Design
PID:961; v1.0.3.0; Last Updated: 12/15/2025
Liangcai Zhang and Ying Yuan
Design parameters
Type I error rate, α (one-sided):
Power, 1-β :
Unpromising response rate, p0 (null hypothesis)
Desirable response rate, p1 (alternative hypothesis)
Maximum sample size, nmax (default set to 100)
Method for Protocol Template:
Optimal
Minimax
Calculate
Design Summary
Protocol Template
Reference
Simon R (1989). Optimal two-stage designs for phase II clinical trials, Controlled Clinical Trials 10: 1-10.