A Bayesian design for phase II clinical trials with delayed responses based on multiple imputation

PID: 981 ; v1.0.1.0 ; Last updated: 12/15/2025

Toxicity

Efficacy

Time to response

Time to progression

Upper limit of toxicity rate (\(\phi_T\))

Lowest acceptable response rate (\(\phi_E\))

Unacceptable progression rate (\(\phi\))

Stop the trial if\(\ Pr\) ( \(p\) > \(\phi_T\) | \(data\) ) > \(C_T\), where \(C_T\) is

Stop the trial if\(\ Pr\) ( \(p\) < \(\phi_E\) | \(data\) ) > \(C_E\), where \(C_E\) is

Stop the trial if\(\ Pr\) ( \(p\) > \(\phi\) | \(data\) ) > \(C\), where \(C\) is

Evaluation time period for the endpoint

Choose txt data file to upload: file template

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