KeyboardComb: the Keyboard Design for Drug Combination Trials

Click here to obtain user guide

Doses

Error: Dose Levels for Drug A must be Less than that of Drug B!

Drug A

Drug B

Number of Doses:

Starting Dose Level:

Target Probability

Target toxicity probability \(\phi\) :

Sample Size

Cohort size:

Number of cohort:

Overdose Control

Eliminate dose \(j\) if\(\ Pr\)(\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)

Use the default cutoff (recommended) \(p_E\) =

Check the box to impose a more stringent safety stopping rule:

Stop the trial if\(\ Pr\) (\(p_1\)> \(\phi\) | \(data\)) > \(p_E\) - \(\delta\), where \(\delta\) is

Decision Table

Simulation Setting

Method to enter simulation scenarios:

Type in

Upload scenario file

Enter Simulation Scenarios

Number of Simulations:

Set Seed:

For each scenario, enter true toxicity rate of each dose combination:

wrong input

Scenario 1:

Scenario 2:

Scenario 3:

Scenario 4:

Scenario 5:

Scenario 6:

Scenario 7:

Scenario 8:

Scenario 9:

Scenario 10:

Error:You already reached the maximum number of scenarios you can enter!

Please upload simulation scenario file with the template: csv file template

Browse...

Number of Simulations:

Set Seed:

Operating Characteristics

Please make sure that you have set up Trial Setting and Simulation before generating the protocol.

Generate trial protocol with html file

Generate trial protocol with word file

Target toxicity probability \(\phi\) :

Number of doses for drug A:

Number of doses for drug B:

Error:Dose Levels for Drug A must be Less than that of Drug B!

Set seed

Enter the number of patients treated at each dose combination:

Enter the number of patients with toxicity at each dose combination:

Next Dose

Target toxicity probability \(\phi\) :

Number of doses for drug A:

Number of doses for drug B:

Error:Dose Levels for Drug A must be Less than that of Drug B!

Enter the number of patients treated at each dose combination:
Enter the number of patients with toxicity at each dose combination:

MTD Selection Result

1. Yan, F., Mandrekar, S. J. & Yuan, Y. (2017). Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-17-0220

KeyboardComb: the Keyboard Design for Drug Combination Trials

V1.2.2.0 ; Last Updated: 08/13/2020

Yanhong Zhou,\(^1\) Haitao Pan,\(^2\) Ruitao Lin,\(^1\) and Ying Yuan\(^1\)

1. Department of Biostatistics, MD Anderson Cancer Center; 2. St. Jude Children's Research Hospital

Trial Setting

Simulation

Trial Protocol

Get Next Dose

Select MTD

Reference

Click here to obtain user guide

Doses

Error: Dose Levels for Drug A must be Less than that of Drug B!

Drug A

Drug B

Number of Doses:

Starting Dose Level:

Target Probability

Sample Size

Overdose Control

Decision Table

Simulation Setting

Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose combination:

Error:You already reached the maximum number of scenarios you can enter!

Operating Characteristics

Please make sure that you have set up Trial Setting and Simulation before generating the protocol.

Error:Dose Levels for Drug A must be Less than that of Drug B!

Next Dose

Error:Dose Levels for Drug A must be Less than that of Drug B!

MTD Selection Result

1. Yan, F., Mandrekar, S. J. & Yuan, Y. (2017). Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-17-0220

2. Pan, H., Lin, R., Zhou, Y., & Yuan, Y. (2020). Keyboard design for phase I drug-combination trials. Contemporary Clinical Trials, 105972.

KeyboardComb: the Keyboard Design for Drug Combination Trials

V1.2.2.0 ; Last Updated: 08/13/2020

Yanhong Zhou,\(^1\) Haitao Pan,\(^2\) Ruitao Lin,\(^1\) and Ying Yuan\(^1\)

1. Department of Biostatistics, MD Anderson Cancer Center; 2. St. Jude Children's Research Hospital

Trial Setting

Simulation

Trial Protocol

Get Next Dose

Select MTD

Reference

Click here to obtain user guide

Doses

Error: Dose Levels for Drug A must be Less than that of Drug B!

Drug A

Drug B

Number of Doses:

Starting Dose Level:

Target Probability

Sample Size

Overdose Control

Decision Table

Simulation Setting

Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose combination:

Error:You already reached the maximum number of scenarios you can enter!

Operating Characteristics

Scenarios entered (Click "CSV" to save for later use if desired).

Scenarios uploaded:

Please make sure that you have set up Trial Setting and Simulation before generating the protocol.

Error:Dose Levels for Drug A must be Less than that of Drug B!

Next Dose

Error:Dose Levels for Drug A must be Less than that of Drug B!

MTD Selection Result

1. Yan, F., Mandrekar, S. J. & Yuan, Y. (2017). Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials. Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-17-0220

2. Pan, H., Lin, R., Zhou, Y., & Yuan, Y. (2020). Keyboard design for phase I drug-combination trials. *Contemporary Clinical Trials*, 105972.

2. Pan, H., Lin, R., Zhou, Y., & Yuan, Y. (2020). Keyboard design for phase I drug-combination trials. Contemporary Clinical Trials, 105972.