Keyboard: a novel Bayesian toxicity probability interval design for phase I clinical trial

How to Use the Keyboard App?

Doses

Number of doses:

Starting dose level:

Error: Starting dose level must be less than the number of doses

Target Probability

Target Toxicity Probability \(\phi\) :

Sample Size

Cohort size:

Number of cohort:

Overdose Control

Eliminate dose \(j\) if\(\ Pr\) (\(p_j\)> \(\phi\) | \(data\)) > \(p_E\)

Use the default cutoff (recommended) \(p_E\) =

Check the box to impose a more stringent safety stopping rule:

Stop the trial if\(\ Pr\) (\(p_1\)> \(\phi\) | \(data\)) > \(p_E\) - \(\delta\), where \(\delta\) is

Decision Table

Simulation

Method to enter simulation scenarios:

Type in

Upload scenario file

Enter Simulation Scenarios

Number of Simulations:

Set Seed:

For each scenario, enter true toxicity rate of each dose level:

Please upload simulation scenario file with the template: csv file template

Browse...

Number of Simulations:

Set Seed:

Operating Characteristics

Please make sure that you have set up Trial Setting and run Simulation before generating the protocol.

Generate trial protocol with html file

Generate trial protocol with word file

Target Toxicity Probability \(\phi\) :

Target Toxicity Probability must be between 0 and 1

Number of doses

Error:You already reached the maximum number of doses you can enter!

Please enter the trial data:

Dose level

Number of patients treated

Number of patients with dose limiting toxicity

MTD Selection Result

v1.2.1.0 ; Last Updated: 07/15/2020

Keyboard: a novel Bayesian toxicity probability interval design for phase I clinical trial

Yanhong Zhou and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center

Trial Setting

Simulation

Trial Protocol

Select MTD

How to Use the Keyboard App?

Doses

Error: Starting dose level must be less than the number of doses

Target Probability

Sample Size

Overdose Control

Decision Table

Simulation

Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose level:

Operating Characteristics

Please make sure that you have set up Trial Setting and run Simulation before generating the protocol.

Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!

Please enter the trial data:

Dose level

Number of patients treated

Number of patients with dose limiting toxicity

MTD Selection Result

v1.2.1.0 ; Last Updated: 07/15/2020

Keyboard: a novel Bayesian toxicity probability interval design for phase I clinical trial

Yanhong Zhou and Ying Yuan

Department of Biostatistics, MD Anderson Cancer Center

Trial Setting

Simulation

Trial Protocol

Select MTD

How to Use the Keyboard App?

Doses

Error: Starting dose level must be less than the number of doses

Target Probability

Sample Size

Overdose Control

Decision Table

Simulation

Enter Simulation Scenarios

For each scenario, enter true toxicity rate of each dose level:

Operating Characteristics

Here is the scenarios entered

Here is the scenarios uploaded

Please make sure that you have set up Trial Setting and run Simulation before generating the protocol.

Target Toxicity Probability must be between 0 and 1

Error:You already reached the maximum number of doses you can enter!

Please enter the trial data:

Dose level

Number of patients treated

Number of patients with dose limiting toxicity

MTD Selection Result