Bayesian Toxicity Monitoring

J. Jack Lee, Ying-Wei Kuo, Diane Liu and Nan Chen

Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030

PID:880; v2.2.3.0 ; Last Updated: 04/22/2021

Calculate Stopping Boundaries

Trial Name (Optional)

Toxicity parameters:

Probability of Dose-limiting Toxicity (\(\theta\))

Maximum probability of Dose-limiting Toxicity allowed (\(\theta_{max}\)):

Prior distribution for \(\theta\): \(\textit{Beta}\)(\(a_0, b_0\))

\(a_0\):

\(b_0\):

Sample and cohort size:

Input Cohorts Manually

Maximum number of patients in the trial

Minimum number of patients before early stopping rule applies

Cohort size

Cohorts: (separate by a comma)

Toxicity stopping criterion:

Stop for excessive toxicity

\(\textit{Prob}\)(\(\theta\ > \theta_{max}\)) \(\ge P_T\)

\(P_T\):

Upload Input file (.csv format): [Sample input file]

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Save Input into a csv file

Filename

Filename

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Operating Characteristics

Trial Name (Optional)

Scenarios:

(separate by a comma)

True Toxicity Rate (in ascending order):

Graph Parameters:

Auto Generated Graph Parameters

(separate by a comma)

Color:

Density:

Angle:

Line Type:

Filename

Filename

Save Input into a csv file

Download PDF Report Download Excel Report

Trial Monitoring

Trial Name (Optional)

Number of Patients

Seq#

Patient ID

Toxicity Outcome

1

2

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Save Input into a csv file

Filename

Filename

Download PDF Report Download Excel Report

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