Upload the previously saved input (a .csv file)
Stop Stage 1 if the number of patients assigned to single dose reaches \(n_{stop}\) and the decision is to stay, where \(n_{stop}\) =
Stage 1: close a dose for backfilling if the number of patients assigned to the dose reaches \(n_{cap}\), where \(n_{cap}\) =
End the backfilling once the dose escalation ends
The number of dose arms in Stage 2 adaptive randomization:
The target number of patients in each dose arm of Stage 2:
The probability of allocating the patient to the dose arm minimizing imbalances:
Eliminate dose \(j\) if\(\ Pr\) (\(p_{_j}\)> \(\phi\) | \(data\)) > \(p_{_E}\)
Check to ensure \( \widehat p_{_{MTD}} \leq \) de-escalation boundary, where \(\widehat p_{_{MTD}}\) is the isotonic estimate of the DLT probability for the dose selected as the MTD.
Maximum tolerable DLT rate \( \widetilde\pi_{_{T}} \):
Minimum acceptable response rate \( \widetilde \pi_{_{E}} \):
The dose identified as OBD must satisfy the following safety and response criteria:
(Safety) \( Pr(\phi>\widetilde \pi_{_{T}}|data)\le: \)
(Response) \( Pr(\phi_{E}<\widetilde \pi_{_{E}}|data)\le: \)
Upload simulation toxicity and response scenarios file using the template: csv file template
Check the box to confirm that design parameters have been entered under Trial Setting.
The number of dose arms:
The number of prognostic factors:
Upload the ID, dose arm and prognostic factors of the enolled patients using the template: csv file template 2
Upload data file using the template: csv file template OBD