Parallel phase I/II clinical trial design
This package consists of C and C++ code for simultaneously evaluating efficacy and toxicities
using a seamless phase I/II design for clinical trials of combination therapies.
This computer code is in support of the publication:
“
A parallel phase I/II clinical trial design for combination therapies. Huang X, Biswas S, Oki Y, Issa JP, Berry DA.
Biometrics, 63(2):429-436, 2007.
”
A copy of the paper is included.
The simulations in the above paper were done in C by Swati Biswas. Her C code is
collected in the (uncompressed ZIP) folder showing her name. After the paper was published,
Dr. L. Wooten wrote a C++ program for the simulation and implementation of another real
trial (other than the one mentioned in the paper). That C++ program is also included here.
For a general combination trial, some modification is needed to use the above programs.
System Requirements for the C++ code (Phase12Xuelin.sln)
- Microsoft Windows XP SP3, Windows Vista SP1, or Windows 7
- Microsoft Visual Studio 2005 compiler
- Also, please see the file called BuildMe.txt