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 File NameSizeNotes
 DoseScheduleFinder_V2.2.0_NoFX2.0.zip  2281 KB No Microsoft .Net Framework included. Assumes you already have the .NET 2.0 Framework installed
 DoseScheduleFinder_V2.2.0_WithFX2.0.zip  25160 KB Includes Microsoft .Net Framework 2.0
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Dose Schedule Finder

Design and conduct Phase I clinical trials that simultaneously optimizes dose and schedule

This software is for designing and conducting Phase I clinical trials that simultaneously optimizes both dose and schedule. The goal is to determine a maximum-tolerated dose and schedule (MTDS) in terms of the overall risk of toxicity. The method is Bayesian adaptive and uses time-to-toxicity as the outcome.

The software is based on the paper Simultaneously optimizing dose and schedule of a new cytotoxic agent, Thomas M Braun, Peter F Thall, Hoang Nguyen, and Marcos de Lima, Clinical Trials 2007; 4: 113–124.





Hoang Nguyen developed the numerical algorithms using Visual C++, and the user interface using C# and the Microsoft .NET framework version 2.0