BMA-CRM Simulator

The BMA-CRM Simulator is an easy-to-use implementation of the BMA-CRM dose finding method, Bayesian Model Averaging Continual Reassessment Method by Guosheng Yin and Ying Yuan.

See also the Method Description and User's Guide available here and also included with the software.

The software was developed by Leiko H. Wooten, J. Clift Norris and John D. Cook, using C# and the Microsoft .NET Framework version 2.0 for the user interface, and Microsoft's Visual C++ 2008 for the calculation engine.

System Requirements

1. Windows XP SP3, Windows Vista SP1 or Windows 7
2. Microsoft .NET Framework version 2.0
3. Microsoft Visual C++ 2008 SP1 Runtime Libraries

If any of the required components is missing, the installation procedure will navigate to the appropriate vendor's download site.

References

1. Guosheng Yin, and Ying Yuan. Bayesian Model Averaging Continual Reassessment Method in Phase I Clinical Trials. To appear in Journal of the American Statistical Association.